Green Tea Research Today is a free monthly online journal that collates and summarizes the latest research about Green Tea, including details on benefits, antioxidants, weight loss, diet, side effects.

Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention.

Ramos S

Department of Metabolism and Nutrition, Instituto del Frío, Consejo Superior de Investigaciones Científicas, 28040 Madrid, Spain. s.ramos@if.csic.es <s.ramos@if.csic.es>

Epidemiological studies have described the beneficial effects of dietary polyphenols (flavonoids) on the reduction of the risk of chronic diseases, including cancer. Moreover, it has been shown that flavonoids, such as quercetin in apples, epigallocatechin-3-gallate in green tea and genistein in soya, induce apoptosis. This programmed cell death plays a critical role in physiological functions, but there is underlying dysregulation of apoptosis in numerous pathological situations such as Parkinson's disease, Alzheimer's disease and cancer. At the molecular level, flavonoids have been reported to modulate a number of key elements in cellular signal transduction pathways linked to the apoptotic process (caspases and bcl-2 genes), but that regulation and induction of apoptosis are unclear. The aim of this review is to provide insights into the molecular basis of the potential chemopreventive activities of representative flavonoids, with emphasis on their ability to control intracellular signaling cascades responsible for regulating apoptosis, a relevant target in cancer-preventive approach.

Published 11 June 2007 in J Nutr Biochem, 18(7): 427-42.
Full-text of this article is available online (may require subscription).

© 2004-2008 Green Tea Research Today. All Rights Reserved.